COLLECTION: Vital Perfection / Target your deepest wrinkles and dark spots with the Vital Perfection Wrinkle Spot Treatment. Rediscover the best version of you. Shiseido’s powerful 2-in-1 treatment visibly reduces wrinkles, smile lines, and dark spots at their root, using breakthrough ReNeura Technology++™ and concentrated retinol. Skin is refined and toned for a more youthful, radiant look. Enhance its effects with the full Vital Perfection routine and reawaken skin's potential. • Retinol (vitamin A) improves the look of wrinkles by maintaining healthy skin turnover for youthful radiance. • 48 hours of moisture helps keep skin plump and protected. Our innovation. Our research. Your results. Visibly reduced wrinkles, smile lines, and dark spots within 4 weeks. Inspired by the fragrance of the noble Japanese orchid, the scent helps awaken the senses. Dermatologist-tested.